Synthesis of 4-chloro-N′-(2-cyanoacetyl)benzohydrazide derivatives, cytotoxicity, VEGFR-2/EGFRT790M bioassays and in silico docking/ADMET studies

Key Points

• Cytotoxicity assessed through bioassays shows effectiveness against specific cancer cell lines—highlighting strong potential for therapeutic applications.
• The study reports on 4-chloro-N′-(2-cyanoacetyl)benzohydrazide derivatives, evaluating their biological activity through conditions mimicking real-world scenarios.
• Assessment through in silico docking reveals promising interactions with key targets like VEGFR-2 and EGFR T790M, suggesting specificity in action.
• Further ADMET studies predict favorable pharmacokinetic properties—this could enable future drug development efforts towards effective cancer treatments.