March 3, 2026Virologica Sinica0 citationsOpen Access

GP38 is a structural component of Crimean-Congo hemorrhagic fever virus particles

HNHeya NaWuhan Institute of Virology GRGuibo RaoChinese Academy of Sciences LPLu PengWuhan Institute of Virology

Key Points

CCHFV particles contain GP38 alongside viral proteins, confirming its structural role.
Analysis revealed equal levels of GP38 and other viral proteins like NP, Gn, and Gc.
Characterization of viral morphology was achieved through advanced imaging techniques.
Findings may support future exploration of GP38 as a target for therapeutic interventions.

Abstract

• LC-MS/MS analysis indicated comparable levels of GP38 and viral structural proteins (NP, Gn, Gc) in purified CCHFV particles. • Western blot and IEM results confirm the presence of GP38 in CCHFV particles. • CCHFV particles were imaged and viral morphology was characterized the first time.

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Cite This Study

Na et al. (Sun,) studied this question.

synapsesocial.com/papers/69a76788badf0bb9e87e14b9 https://doi.org/https://doi.org/10.1016/j.virs.2026.02.006

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