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February 6, 2026SHILAP Revista de lepidopterologíaOpen Access

First 2-year experience of nationwide newborn screening for severe forms of T and B cell immunodeficiency: 2.3 million newborns analyzed using TREC and KREC in Russia

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Key Points

Identification of a broad spectrum of immunodeficiencies reduces the risk of severe infections and organ damage.
Timely intervention includes treatments such as hematopoietic stem cell transplantation and immunoglobulin replacement therapy.
Assessment involved a large-scale application of TREC and KREC testing across 2.3 million newborns in Russia.
Future improvements focus on enhancing protocols and individualized medical management for affected infants.

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Implication

Nationwide analysis demonstrates effective newborn screening for immunodeficiencies, suggesting improved treatments for infants.

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Cite This Study

Marakhonov et al. (2026) studied this question.

synapsesocial.com/papers/69a76791badf0bb9e87e1736 https://doi.org/10.3389/fimmu.2026.1742811

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