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Turn CAR T against TAMs | Synapse
March 3, 2026
Turn CAR T against TAMs
AM
Alberto Mantovani
CG
Cecília Garlanda
Humanitas University
Key Points
CAR T therapy shows promise in reducing tumor-associated macrophages, improving immune response.
The analysis reports a significant decrease in cytokine levels associated with macrophage activity.
Targeting the tumor microenvironment with CAR T therapy may enhance tumor clearance.
Findings support the potential reprogramming of immune responses in cancer treatments.
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Mantovani et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76808badf0bb9e87e3525
https://doi.org/https://doi.org/10.1016/j.ccell.2026.01.008
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