Alpha-fetoprotein acts as a key regulator of cancer stemness in hepatocellular carcinoma via PI3K/Akt pathway

Key Points

• Cancer stemness is significantly influenced by alpha-fetoprotein in hepatocellular carcinoma.
• The study found that alterations in the PI3K/Akt pathway correspond to changes in cancer stemness.
• This analysis employed biochemical assays to evaluate the impact of alpha-fetoprotein on stem cell-like properties.
• Highlights the importance of targeting alpha-fetoprotein in therapeutic strategies for hepatocellular carcinoma.