Impact of disintegrants on the structure and disintegration of hydroxypropyl methylcellulose-based amorphous solid dispersion tablets

Key Points

• Tablets exhibited enhanced disintegration due to the incorporation of disintegrants, improving dissolution rates.
• Key evidence showed a significant increase in disintegration time variation across different disintegrants used in the study.
• Analysis of disintegration properties contrasts various disintegrants in hydroxypropyl methylcellulose-based tablets.
• Findings may enable better formulation strategies for enhancing drug delivery using solid dispersion techniques.