A2AR antagonist IDPU facilitates the restoration of mitochondrial dynamics in 6-OHDA-induced primary mid-brain neuronal cells, via regulating p38MAPK/Parkin/DJ-1/DRP1 axis

Key Points

• Mitochondrial dynamics significantly improve following treatment with a2ar antagonist IDPU.
• Healing of mitochondrial function occurs through the p38MAPK/Parkin/DJ-1/DRP1 axis.
• Observed effects in 6-OHDA-induced primary mid-brain neuronal cells highlight potential neuroprotective strategies.
• The findings indicate that a2ar antagonism may offer new directions for treatments targeting mitochondrial dysfunction.