March 3, 2026Open Access

Buyang Huanwu Decoction attenuates vascular aging by suppressing the pathway of neutrophil extracellular trap formation via modulation of the HMGB1/TLR4/p38 signaling pathway

Key Points

BHD alleviates vascular aging by suppressing the formation of neutrophil extracellular traps.
The main finding shows a novel mechanism involving the HMGB1-TLR4-p38 signaling cascade.
The analysis indicates that BHD acts as an immunomodulatory agent targeting vascular aging pathways.
These insights highlight the potential of holistic treatments for vascular aging, warranting further investigation.

Abstract

For the first time, our findings unveil a novel mechanism whereby BHD alleviates vascular aging by modulating the immune microenvironment through inhibition of the HMGB1-TLR4-p38-NETs cascade. These findings provide a novel immunomodulatory perspective on BHD and highlight its potential as a holistic therapeutic strategy against vascular aging.

Buyang Huanwu Decoction attenuates vascular aging by suppressing the pathway of neutrophil extracellular trap formation via modulation of the HMGB1/TLR4/p38 signaling pathway

Key Points

Abstract

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