Differential effect of Periodontal pathogen Fusobacterium nucleatum and Porphyromonas gingivalis on modulation of specific partial-EMT genes in colorectal cancer cells

Key Points

• Specific partial-EMT gene modulation occurs in colorectal cancer cells influenced by pathogens.
• Fusobacterium nucleatum and Porphyromonas gingivalis exert differential effects, indicating varied interactions.
• Observational analysis of colorectal cancer cell lines reveals significant alterations in gene expression profiles.
• These findings highlight the potential role of oral pathogens in cancer progression and the tumor microenvironment.