What question did this study set out to answer?

This research aims to examine the connection between periodontal health and non-alcoholic fatty liver disease using multiple assessment tools.

March 4, 2026Open Access

Nonalcoholic fatty liver disease assessed by multiple tools are correlated to periodontal conditions

THTakatoshi HiroshimayaKagoshima University KIKomei IwaiAsahi University MMMarika MarutaniKagoshima University

Key Points

This research aims to examine the connection between periodontal health and non-alcoholic fatty liver disease using multiple assessment tools.
Conducted a survey with 2,453 participants visiting a dental clinic.
Evaluated periodontitis using the Community Periodontal Index (CPI).
Assessed NAFLD using Fibrosis-4, NAFLD fibrosis score, and Fatty Liver Index.
Performed logistic regression analyses to determine relationships between periodontal measurements and NAFLD outcomes.
Significant association found between PPD ≥ 6 mm and NFS > 0.675 (OR = 4.11).
PPD ≥ 6 mm also significantly associated with FLI ≥ 60 (OR = 1.76).
Participants with BOP positive showed an association between PPD ≥ 6 mm and FLI ≥ 60 (OR = 1.68).
No association was observed in participants without BOP.

Abstract

This study aimed to clarify the relationship between periodontitis and non-alcoholic fatty liver disease (NAFLD). A survey was conducted with 2,453 participants who visited the dental clinic at the Asahi University Hospital. Periodontitis was evaluated using the Community Periodontal Index (CPI), and NAFLD was evaluated using multiple tools such as Fibrosis-4 (FIB4), NAFLD fibrosis score (NFS), and Fatty Liver Index (FLI). The relationship between periodontitis and the cutoff values of three NAFLD assessment tools by logistic regression analyses indicated that PPD ≥ 6 mm was significantly associated with NFS > 0.675 (OR = 4.11, 95%CI:1.06–15.99) and with FLI ≥ 60 (OR = 1.76, 95%CI:1.12–2.76). The participants with BOP positive indicated a significant association between PPD ≥ 6 mm and FLI ≥ 60 (OR = 1.68, 95%CI:1.05–2.70). However, no association was found in participants without BOP. These results suggest that periodontal inflammation is associated with NAFLD, as assessed using the FLI.

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