What question did this study set out to answer?

The study aims to identify molecular factors influencing resistance to chemoradiotherapy in muscle-invasive bladder cancer and explore the role of ferroptosis suppression.

March 4, 2026Journal of Clinical Oncology

Ferroptosis suppression and its association with chemoradiotherapy resistance in muscle-invasive bladder cancer.

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Authors

TTTAKUYA TSUJINOOsaka University of Pharmaceutical Sciences SYShogo YamazakiOsaka University of Pharmaceutical Sciences KNKazuki NishimuraOsaka University of Pharmaceutical Sciences

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Implication

Integrated analysis reveals ferroptosis suppression as a key factor in chemoradiotherapy resistance in muscle-invasive bladder cancer, indicating personalized treatment approaches.

Key Points

The study aims to identify molecular factors influencing resistance to chemoradiotherapy in muscle-invasive bladder cancer and explore the role of ferroptosis suppression.
Conducted transcriptomic profiling of pre-treatment tumors from 179 patients undergoing bladder-preserving treatment.
Utilized bladder cancer cell models for RNA sequencing, lipidomic profiling, and CRISPR/Cas9 screening to identify molecular determinants of resistance.
Analyzed correlations between ferroptosis suppressor gene expression and clinical outcomes.
Patients with high ferroptosis suppressor signature exhibited poorer responses to chemoradiotherapy and shorter survival times.
Ferroptosis suppression was associated with immune-excluded microenvironments and distinct transcriptional patterns.
CRISPR/Cas9 screening identified key genes related to ferroptosis suppression that are potential targets for enhancing radiosensitivity.

Cite This Study

TSUJINO et al. (2026) studied this question.

synapsesocial.com/papers/69a7cc9fd48f933b5eed84ae https://doi.org/10.1200/jco.2026.44.7_suppl.839

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Implication

Integrated analysis reveals ferroptosis suppression as a key factor in chemoradiotherapy resistance in muscle-invasive bladder cancer, indicating personalized treatment approaches.

Ferroptosis suppression and its association with chemoradiotherapy resistance in muscle-invasive bladder cancer.

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Implication

Key Points

Cite This Study

Ferroptosis suppression and its association with chemoradiotherapy resistance in muscle-invasive bladder cancer.

Discussion

Member takes

Implication

Key Points

Cite This Study

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