Demonstrates a green approach to bis-heterocycle synthesis using periodic acid in water, indicating sustainable practices in chemistry.
Periodic acid promotes metal-free methylenation of imidazoheteroarenes using ethylene glycol as a green C1 source. The reaction proceeds in water, delivers yields up to 97%, & is scalable, offering a sustainable approach to bis-heterocycle synthesis.
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Franco et al. (2026) studied this question.
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