Rational design of click-assembled chiral dendrimers: anticancer activity and molecular dynamics study

Key Points

• To design and evaluate chiral dendrimers for anticancer activity using click chemistry.
• Design and synthesize chiral dendrimers through click chemistry.
• Evaluate anticancer activity in vitro.
• Assess selectivity and binding to ERα.
• The fully chiral dendrimer exhibited the highest anticancer activity.
• Demonstrated good selectivity for cancer cells.
• Showed stable binding to the estrogen receptor (ERα).