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March 4, 2026

Associations of Adiposity With Gut Microbiota Composition Among Adults-Results From a Federated Analysis of Individual Participant Data From Eight European Observational Studies.

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Authors

CSCarolina SchwedhelmMPMariona PinartSFSofia Kirke Forslund-Startceva

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Overview

Federated analysis reveals associations between BMI and gut microbiota in adults, suggesting new insights into disease risk.

Key Points

  • This research investigates how body mass index (BMI) affects the composition of gut microbiota in adults.
  • Conducted a federated analysis of data from eight European observational studies.
  • Analyzed associations between BMI and gut microbiota at the phylum and genus levels.
  • Used 16S rRNA amplicon sequencing and metagenomic techniques.
  • Examined the relationship between BMI and microbial diversity and abundance.
  • Higher BMI was linked to lower alpha diversity of gut microbiota.
  • BMI positively correlated with the abundance of Proteobacteria.
  • A decrease in Faecalibacterium abundance was associated with increasing BMI.
  • Odds of detecting Dorea, Streptococcus, Clostridium, and Collinsella increased with higher adiposity.

Cite This Study

Schwedhelm et al. (2026) studied this question.

synapsesocial.com/papers/69a7ccd5d48f933b5eed8aa3https://doi.org/10.1111/obr.70106
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