Genetic toxicology is a scientific and practical discipline that emerged from fundamental research of the mechanisms maintaining the stability of genetic material. Its primary objectives the early detection of potentially harmful genotoxic agents threatening human health and the prevention of their adverse effects. Despite a certain conservatism cigarette toxicology, caused by the need of strictly adhering to validated and standardized protocols for assessing genotoxic risks, this field is constantly evolving. Such development would not be possible without deep knowledge of physiological processes. The foundation for understanding the physiological aspects of the mutation process was laid by Mikhail E. Lobashev, whose works set the direction of scientific research for many years. The practical result of this research was the development of highly sensitive tests for genetic toxicology and reduction of risks associated with hereditary, oncological and other diseases.
E. I. Stepchenkova (2025) studied this question.