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March 4, 2026Pathophysiology1 citationsOpen Access

Redefining Obstructive Sleep Apnea Treatment for Modern Clinical Practice

Redefining Obstructive Sleep Apnea: Treatment in the Modern Era

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Authors

JRJose RedondoKAKori AscherAAAlexandre R. Abreu

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Overview

Narrative review explores advanced treatments for OSA, highlighting individualized therapies and efficacy.

Key Points

  • This review aims to evaluate contemporary treatment options for obstructive sleep apnea that go beyond CPAP.
  • Conducted a narrative review integrating evidence from randomized controlled trials, cohorts, and mechanistic studies.
  • Examined various therapies, including oral appliances, surgeries, and pharmacological interventions.
  • Evaluated outcomes like apnea-hypopnea index (AHI), oxygenation, and patient-reported symptoms.
  • Mandibular advancement devices showed better adherence and symptom relief in mild-to-moderate OSA compared to placebo.
  • Maxillomandibular advancement surgery was highly effective for severe OSA with durable results.
  • Hypoglossal nerve stimulation demonstrated substantial improvements and high adherence rates, supported by various studies.
  • Pharmacotherapy targeting metabolic factors resulted in significant reductions in AHI and cardiometabolic risks in obesity-related OSA.

Cite This Study

Redondo et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd1dd48f933b5eed931ehttps://doi.org/10.3390/pathophysiology33010020
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