Halogen Atom Transfer-Induced Radical Cascades Cyclization of N-(o-Cyanobiaryl)acrylamides with Alkyl Halides via Boryl Radical-Mediated

Long‐Jin Zhong; Xuan Shang; Pengfei Huang; Quan Zhou; Changhui Liu; Yu Liu

doi:10.1039/d5qo01481f

January 1, 2026Organic Chemistry Frontiers

Halogen Atom Transfer-Induced Radical Cascades Cyclization of N-(o-Cyanobiaryl)acrylamides with Alkyl Halides via Boryl Radical-Mediated

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Key Points

The central aim is to explore boryl radical techniques for synthesizing polycyclic nitrogen compounds using an XAT strategy.
Utilized ligated boryl radicals under photocatalytic conditions
Implemented halogen-atom transfer for cyclization
Synthesis focused on N-(o-Cyanobiaryl)acrylamides with alkyl halides
Successfully synthesized nitrogen-containing polycyclic compounds
Demonstrated efficiency of the boryl radical-mediated approach through XAT
Achieved high selectivity for cyclization products

Implication

Demonstrates halogen-atom transfer-induced cyclization of nitrogen compounds, suggesting a new synthetic route for polycyclic structures.

Abstract

We report a study on the use of ligated boryl radicals for the synthesis of nitrogen-containing polycyclic compounds under photocatalytic conditions through a halogen-atom transfer (XAT) strategy. This approach leverages...

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Cite This Study

Zhong et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd3dd48f933b5eed9725 https://doi.org/10.1039/d5qo01481f

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Halogen Atom Transfer-Induced Radical Cascades Cyclization of N-(o-Cyanobiaryl)acrylamides with Alkyl Halides via Boryl Radical-Mediated

Key Points

Implication

Abstract

Discussion

Cite This Study

Halogen Atom Transfer-Induced Radical Cascades Cyclization of N-(o-Cyanobiaryl)acrylamides with Alkyl Halides via Boryl Radical-Mediated

Key Points

Implication

Abstract

Discussion

Cite This Study

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