Synergistic Inhibitory Effect and Mechanism of Action of Cinnamaldehyde-Carvacrol Nanoemulsion on the Staphylococcus aureus and Escherichia coli Mixed Biofilms Formation.
Demonstrates the synergistic effect of cinnamaldehyde-carvacrol nanoemulsion in inhibiting biofilm formation in bacterial infections, suggesting a potential treatment method.
Key Points
Investigate the inhibitory effects of cinnamaldehyde and carvacrol on mixed biofilms of S. aureus and E. coli.
Evaluated the synergy between cinnamaldehyde and carvacrol for biofilm inhibition.
Prepared cinnamaldehyde-carvacrol nanoemulsion for enhanced effects.
Assessed bacterial adhesion, motility, and polysaccharide production.
Tested efficacy in a mouse model infected with S. aureus and E. coli.
Q value indicating synergy of 2.28 for essential oil combination.
Nanoemulsion significantly inhibited biofilms at a concentration of 64 μg/mL.
Reduced bacterial adhesion and motility, and inhibited PIA synthesis.
Marked reduction in bacterial burden in the infected implant model.