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March 1, 2026Journal of Clinical Oncology

MTAP loss in penile squamous cell carcinoma (penSCC): A genomic landscape study.

Eyal Kord Dean C. Pavlick Ole Gjoerup Petros Grivas Sumanta Kumar Pal Neeraj Agarwal Shilpa Gupta Roger Li A. Kamat J L Lortat Jacob Alina Basnet Liang Cheng Douglas I. Lin Hanan Goldberg Andrea Necchi Gennady Bratslavsky Jeffrey S. Ross R. Graf Philippe Edouard Spiess

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Key Points

The study aims to explore the genomic landscape of penile squamous cell carcinoma (penSCC) with a focus on MTAP loss and its implications for treatment.
Analyzed 459 advanced penSCC samples using FoundationOne CDx assay for genomic profiling.
Determined microsatellite instability (MSI) and tumor mutation burden (TMB) from sequencing data.
Measured PD-L1 expression via immunohistochemistry.
Identified MTAP loss in 6.5% of advanced penSCC cases with complete loss of all 8 exons in 70% of those cases.
Found significant co-deletion of CDKN2A and CDKN2B in MTAP loss+ cases compared to MTAP wild type.
Observed similar MSI, TMB, and PD-L1 expression levels between MTAP loss+ and MTAP loss- groups.

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Implication

Genomic profiling reveals MTAP loss in penile squamous cell carcinoma, suggesting targeted therapy opportunities.

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Cite This Study

Kord et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd4fd48f933b5eed98a3 https://doi.org/10.1200/jco.2026.44.7_suppl.11

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