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January 1, 2026Journal of Materials Chemistry B

Control of site-specific deprotonation through mechanochemical interconversion of two ionic cocrystal forms of resveratrol

Bowyn D Ziebarth Liulei Ma Gary C. George KRISTIN HUTCHINS

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Key Points

This research aims to investigate how mechanical processes can control the deprotonation of resveratrol when combined with ionic cocrystal forms.
Utilized mechanochemical techniques to interconvert cocrystal forms of resveratrol.
Analyzed changes in deprotonation at specific sites within the cocrystals.
Examined the effects on drug properties and efficacy.
Successfully demonstrated site-specific deprotonation control through mechanochemical methods.
Showed that different ionic cocrystal forms can alter the drug's properties.
Identified potential for improved efficacy in drug applications.

Implication

Research uncovers how mechanochemical methods influence drug properties in multicomponent formulations, suggesting new avenues for enhancement.

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Cite This Study

Ziebarth et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd5ed48f933b5eed99ed https://doi.org/10.1039/d5tb02000j

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