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March 4, 2026Organic Chemistry Frontiers2 citations

EtAlCl2 -Promoted Defluorinative Thiolation of α-Trifluoromethyl Alkenes

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XGXin GuoGPGuoliang PuXLXiao Long

Key Points

  • This research aims to explore the defluorinative thiolation of α-trifluoromethyl alkenes using EtAlCl2 to enhance synthetic pathways.
  • Utilized EtAlCl2 as a catalyst
  • Examined the reaction of trifluoromethyl alkenes
  • Analyzed the formation of trisubstituted products
  • Achieved complete substitution of all three fluorine atoms
  • Successfully synthesized trisubstituted products
  • Demonstrated a novel pathway for thiolation of alkenes

Abstract

Here, we report a EtAlCl2-promoted thiolation of trifluoromethyl alkenes, which leads to the complete substitution of all three fluorine atoms and affords trisubstituted products. Although the transformation proceeds through a...

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Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd7ed48f933b5eed9d6ehttps://doi.org/10.1039/d6qo00011h
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