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Reports differences in disease severity and arthritis prevalence among FMF siblings with identical genotypes, suggesting age-related evolution.
This study shows that while main clinical features are largely concordant among siblings with identical genotypes, notable differences in disease severity scores and arthritis prevalence exist. These differences are likely attributable to diagnostic delays and age-related disease evolution rather than intrinsic phenotypic divergence.
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Tunce et al. (2026) studied this question.
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