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March 4, 2026Signal Transduction and Targeted TherapyOpen Access

GPR54 regulates non-small cell lung cancer development via dopa decarboxylase

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Authors

HHHyun-Ha HwangSLSeo Yeon LeeCLChanhee Lee

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Overview

Demonstrates GPR54 regulates NSCLC development through DDC, suggesting new therapeutic avenues.

Key Points

  • To investigate the role of GPR54 in the development of non-small cell lung cancer (NSCLC) and its interaction with dopa decarboxylase (DDC).
  • Utilized a mutant Kras-driven mouse lung cancer model with adenoviral-mediated Gpr54 deletion.
  • Conducted RNA sequencing to assess gene expression changes in NSCLC tissues.
  • Performed phosphoprotein arrays to examine effects on signaling pathways.
  • Analyzed the effects of Gpr54 deletion and GPR54 knockdown in human NSCLC cell lines.
  • Gpr54 deletion significantly reduced NSCLC development in mutant Kras mice.
  • Induced apoptotic cell death in NSCLC cell lines upon GPR54 knockdown.
  • Altered expression of genes related to glycolysis and DDC in response to Gpr54 deletion.
  • DC regulated NF-κB phosphorylation and contributed to NSCLC cell proliferation in vitro.

Cite This Study

Hwang et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd9dd48f933b5eeda1b4https://doi.org/10.1038/s41392-026-02591-x
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