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March 4, 2026Journal of Clinical Neuromuscular Disease0 citations

What Is in the Myopathy Literature?

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MIMichael IsfortDLDavid Lacomis

Key Points

  • The aim is to summarize current literature on various myopathies and their treatable aspects.
  • Discussed lipid storage myopathies related to sertraline and ranolazine.
  • Reviewed monoclonal gammopathy-associated myopathies including glycogen storage myopathy.
  • Highlighted reports on statins, toxic myopathy, and immune-mediated myopathies.
  • Covered muscular dystrophies, focusing on specific types like dystrophinopathies.
  • Explored enzyme replacement therapy in Pompe disease.
  • Identified several treatable forms of myopathies related to lipid storage and monoclonal gammopathy.
  • Highlighted the treatment-responsive nature of certain myopathy disorders.
  • Presented data on muscular dystrophies, emphasizing types with potential therapies.
  • Reviewed findings on enzyme replacement therapy efficacy in Pompe disease.

Abstract

This update begins with a discussion of treatable lipid storage myopathies associated with the use of sertraline and ranolazine. We then turn to monoclonal gammopathy-associated myopathies including a more recently identified disorder that is also treatment-responsive, monoclonal gammopathy-associated glycogen storage myopathy. Several reports on statins and muscle symptoms, toxic myopathy, and immune-mediated necrotizing myopathy follow. Other autoimmune myopathy topics are highlighted. Then, muscular dystrophies are covered with a focus on dystrophinopathies, limb-girdle muscular dystrophy, and facioscapulohumeral muscular dystrophy. Pompe disease follows with a focus on enzyme replacement therapy data. A short section on congenital myopathies precedes a review of reports on myotonic dystrophies and nondystrophic myotonias.

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Cite This Study

Isfort et al. (2026) studied this question.

synapsesocial.com/papers/69a7cdaed48f933b5eeda310https://doi.org/10.1097/cnd.0000000000000559
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