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This forum article explores how extravillous trophoblasts activate immune cells to enhance tolerance in pregnancy, suggesting important interactions.
During pregnancy, complex interactions of maternal immune cells and fetal extravillous trophoblasts (EVTs) orchestrate placentation, immune tolerance, and immune defense. This forum article highlights important discoveries and outstanding questions on how the activation of decidual natural killer and T cells, through recognition of key EVT ligands, promotes placentation, tolerance, and immunity.
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Tamara Tilburgs (2026) studied this question.
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