What question did this study set out to answer?

This study aims to uncover the role of miR-19b-3p in the communication between colorectal cancer cells and endothelial cells within the tumor microenvironment.

March 5, 2026SHILAP Revista de lepidopterologíaOpen Access

MiR-19b-3p facilitates colorectal cancer metastasis by mediating the crosstalk between tumor-associated endothelial cells and malignant cells

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Authors

YCYixin CaoJiangsu University JZJia ZhangJiangsu University XKXinyu KaiJiangsu University

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Implication

Functional analysis reveals miR-19b-3p drives metastasis in colorectal cancer, indicating therapeutic potential.

Key Points

This study aims to uncover the role of miR-19b-3p in the communication between colorectal cancer cells and endothelial cells within the tumor microenvironment.
Functional assays using CRC cells (HCT116) and human umbilical vein endothelial cells (HUVECs)
Molecular analyses of miR-19b-3p effects
Co-culture model to study intercellular interactions
In vivo validation with mouse peritoneal tumor model
Measurement of circulating miR-19b-3p in CRC patient samples
miR-19b-3p enhances epithelial-to-mesenchymal transition (EMT) in CRC cells by inhibiting ZMYND11 and activating the MAPK pathway
HUVECs showed endothelial-to-mesenchymal transition (EndMT) due to miR-19b-3p upregulation of SOX9
The co-culture model exhibited a bidirectional increase of miR-19b-3p levels in both cell types
Increased miR-19b-3p in mice led to greater peritoneal tumor burden and EMT marker expression
Higher circulating levels of miR-19b-3p in CRC patients correlated with advanced disease stage and poor prognosis

Cite This Study

Cao et al. (2026) studied this question.

synapsesocial.com/papers/69a91cf1d6127c7a504bfccb https://doi.org/10.3389/fonc.2026.1701701

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MiR-19b-3p facilitates colorectal cancer metastasis by mediating the crosstalk between tumor-associated endothelial cells and malignant cells

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Implication

Key Points

Cite This Study

MiR-19b-3p facilitates colorectal cancer metastasis by mediating the crosstalk between tumor-associated endothelial cells and malignant cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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