What does this research mean for the field?

An efficient intramolecular DBU-catalyzed Rauhut-Currier reaction enables the synthesis of functionalized biaryl-fused cycloheptatriene derivatives with high yields and diastereoselectivities. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To develop an efficient method for synthesizing functionalized biaryl-fused cycloheptatriene derivatives via intramolecular cyclization.

March 5, 2026

Rauhut–Currier Reaction-Inspired Intramolecular Cyclization Approach Using DBU to Access Biaryl-Fused Cycloheptatriene Derivatives

Key Points

To develop an efficient method for synthesizing functionalized biaryl-fused cycloheptatriene derivatives via intramolecular cyclization.
Utilized DBU as a catalyst in the Rauhut-Currier reaction
Assessed broad substrate compatibility
Evaluated products for yield and diastereoselectivity
Explored scalability for gram-scale synthesis
Products were obtained in good to excellent yields
High diastereoselectivity was consistently achieved
Process demonstrated excellent scalability and ease of postsynthetic functionalizations

Abstract

In this paper, an efficient intramolecular DBU-catalyzed Rauhut-Currier reaction has been described to access functionalized biaryl-fused cycloheptatriene derivatives. The method is operationally simple, displays broad substrate compatibility, and consistently delivers the products in good to excellent yields with high diastereoselectivities. The scalability of the process to gram-scale syntheses, combined with facile postsynthetic functionalizations, underscores the flexibility and usefulness of this strategy.

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Authors

Prashant Kumar Sinha

Ravula Shivakumar

Jagadeesh Babu Nanubolu

Journals

Organic Letters

Actions

Institutions

Academy of Scientific and Innovative Research

Indian Institute of Chemical Technology

Institute of Crystallography

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Rauhut–Currier Reaction-Inspired Intramolecular Cyclization Approach Using DBU to Access Biaryl-Fused Cycloheptatriene Derivatives

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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