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March 5, 2026Journal of Medical MicrobiologyOpen Access

Trimethoprim: bactericidal or bacteriostatic activity is dependent on bacterial growth conditions

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Authors

CCCailean CarterJWJohn WainGLGemma C. Langridge

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Overview

Examines trimethoprim's effects on bacteria, highlighting its dual activity based on environmental conditions.

Key Points

  • The research investigates how trimethoprim's activity varies between bactericidal and bacteriostatic based on bacterial growth conditions.
  • Analyzed the effects of trimethoprim under different growth media conditions
  • Assessed the presence of nucleosides and amino acids in the media
  • Investigated the mechanism of action related to DNA synthesis and cell death
  • Trimethoprim showed bacteriostatic effects in the absence of nucleosides
  • Bactericidal effects were observed when nucleosides, glycine, and methionine were present
  • Mechanism of bactericidal activity linked to inhibition of DNA synthesis and activation of mazEF suicide module

Cite This Study

Carter et al. (2026) studied this question.

synapsesocial.com/papers/69a91d8dd6127c7a504c0635https://doi.org/10.1099/jmm.0.002129
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