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Novel benzophenones exhibit cytotoxic effects in cancer cells, indicating potential therapeutic applications.
To clarify the cytotoxic potential of Mesua caudata (King) Kosterm., three novel benzophenone derivatives, mesucaudatins A-C (1-3), along with one known xanthone compound (4), were found in the stem bark of this plant. The structure determination of all benzophenones (1-3) was carried out by 1D (¹H,¹³C) or 2D (HMQC, HMBC) NMR spectroscopy, and high-resolution MS data. All isolates from this plant were first tested for cytotoxicity against cervical (HeLa) and breast cancer (MCF-7) cells. Mesucaudatin A (1) exhibited potent cytotoxic activity against HeLa cells and MCF-7 cells with IC₅₀ values of 0.76 and 9.29 μM, respectively. Macluraxanthone (4) also showed high activity against HeLa cells (IC₅₀ = 3.96 μM) and moderate activity against MCF-7 cells (IC₅₀ = 10.10 μM).
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Tanjung et al. (2026) studied this question.
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