Efficacy and Safety of Pharmacologic Therapies in Acromegaly: A Systematic Literature Review and Network Meta-Analysis

Key Points

• To evaluate the safety and efficacy of pharmacologic therapies for treating acromegaly through a systematic review and network meta-analysis.
• Conducted a systematic literature review of recent randomized controlled trials (RCTs) on acromegaly treatments.
• Performed network meta-analysis to compare the efficacy and safety of pharmacologic therapies.
• Analyzed discontinuation patterns related to adverse events (AEs).
• Paltusotine demonstrated favorable efficacy compared to traditional injectable somatostatin receptor ligands (SRLs).
• Safety profiles of therapies were assessed, showing promising outcomes for Paltusotine.
• Discontinuation related to AEs was notably lower with Paltusotine compared to other treatments.