Clinical and immunological implications of lymphocyte-activation gene 3 expression in metastatic colorectal cancer

Yi‐Hsuan Huang; Shang-Yin Wu; Chung Ta Lee; Bing-Syuan Chung; Peng-Chan Lin; Ren-Hao Chan; Po-Chuan Chen; B. W. Lin; Meng-Ru Shen; Shang-Hung Chen; Yu-Min Yeh

doi:10.1007/s00262-026-04344-9

March 3, 2026Cancer Immunology ImmunotherapyOpen Access

Clinical and immunological implications of lymphocyte-activation gene 3 expression in metastatic colorectal cancer

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Key Points

To evaluate the clinical and immunological significance of LAG3 expression in metastatic colorectal cancer (mCRC).
Analyzed LAG3 expression levels in colorectal cancer samples.
Examined the role of Galectin-9-TIM-3 signaling in LAG3+CD8+ T cells.
Proposed combinational immunotherapy strategies based on findings.
LAG3 expression serves as an independent prognostic biomarker for mCRC.
Galectin-9-TIM-3 signaling may limit the effectiveness of LAG3 blockade.
Combinational immunotherapies could enhance treatment outcomes.

Implication

Uncovers lag3 as a prognostic biomarker in metastatic colorectal cancer, suggesting new immunotherapy approaches.

Abstract

LAG3 expression is an independent prognostic biomarker of mCRC. The distinct Galectin-9-TIM-3 signaling in LAG3⁺CD8⁺ T cells may contribute to limited therapeutic efficacy of LAG3 blockade, suggesting potential combinational immunotherapy strategies.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69a91dc3d6127c7a504c0ebc https://doi.org/10.1007/s00262-026-04344-9

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Clinical and immunological implications of lymphocyte-activation gene 3 expression in metastatic colorectal cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Clinical and immunological implications of lymphocyte-activation gene 3 expression in metastatic colorectal cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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