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March 3, 2026Translational Vision Science & TechnologyOpen Access

Left–Right Determination Factor 2 (LEFTY2) Is an Aqueous Humor Biomarker for Exfoliation Glaucoma

Andrew J. O. Smith Arsham Sheybani Michael Greenwood Erin G. Sieck Linda Tsai James Liu Carla J. Siegfried Ying Liu Ying-Bo Shui Lilly Alcia Yagual González W. Daniel Stamer Steven Bassnett

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Key Points

The study aims to identify new biomarkers for exfoliation glaucoma (XFG) to enhance early diagnosis and management.
Analyzed aqueous humor samples
Examined biomarkers correlating with XFG
Utilized biomarker detection techniques
LEFTY2 identified as a significant biomarker for XFG
Early detection of XFG improved with LEFTY2 measurement
Potential for better management strategies for glaucoma through biomarker monitoring

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Implication

This biomarker study identifies LEFTY2 in aqueous humor, suggesting improved detection for glaucoma.

Abstract

Identification of biomarkers for XFG may improve early detection and treatment.

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Cite This Study

Smith et al. (2026) studied this question.

synapsesocial.com/papers/69a91dd2d6127c7a504c1003 https://doi.org/10.1167/tvst.15.3.4

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