Cu(II)/I2 Mediated Synthesis of α-Keto Esters via Csp2 -Csp Bond Cleavage of 1,2-Alkynediones Followed by C-O Bond Formation

Abdul Khaliq Naveed; Sanghapal D. Sawant

doi:10.1039/d6nj00240d

January 1, 2026New Journal of Chemistry

Cu(II)/I2 Mediated Synthesis of α-Keto Esters via Csp2 -Csp Bond Cleavage of 1,2-Alkynediones Followed by C-O Bond Formation

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Key Points

The study aims to develop an efficient method for synthesizing α-keto esters from 1,2-alkynediones.
Utilized a copper(II)/iodine-mediated reaction
Focused on selective cleavage of C(sp²)–C(sp) bonds
Analyzed products formed through C-O bond formation
Successfully synthesized α-keto esters via the new method
Demonstrated high selectivity in bond cleavage
Showed potential for broader applications in organic synthesis

Implication

An efficient method synthesizes alpha-keto esters in alkynediones, suggesting new pathways for organic synthesis.

Abstract

Herein, we disclose an efficient method for the synthesis of α-keto esters through a copper(II)/iodine-mediated reaction. The transformation involves the selective cleavage of the C(sp²)–C(sp) bond of 1,2-alkynediones, which is...

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Cite This Study

Naveed et al. (2026) studied this question.

synapsesocial.com/papers/69a91de0d6127c7a504c1279 https://doi.org/10.1039/d6nj00240d

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Cu(II)/I2 Mediated Synthesis of α-Keto Esters via Csp2 -Csp Bond Cleavage of 1,2-Alkynediones Followed by C-O Bond Formation

Key Points

Implication

Abstract

Discussion

Cite This Study

Cu(II)/I2 Mediated Synthesis of α-Keto Esters via Csp2 -Csp Bond Cleavage of 1,2-Alkynediones Followed by C-O Bond Formation

Key Points

Implication

Abstract

Discussion

Cite This Study

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