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March 5, 20260 citations

The correlation between circulating DNA fragments, inflammation, oxidative stress biomarkers, and progressive multiple sclerosis: a case-control study.

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RLRun LiNingxia Medical UniversityLYLi YangNingxia Medical UniversityJYJuan YangNingxia Medical University

Key Points

  • This study aims to explore the relationship between circulating DNA fragments and biomarkers of inflammation and oxidative stress in progressive multiple sclerosis (PMS).
  • Conducted a case-control design comparing PMS patients with controls.
  • Measured parameters of circulating DNA and inflammatory and oxidative stress biomarkers.
  • Analyzed the correlation between cfDNA levels and the biomarkers.
  • cfDNA parameters were significantly altered in PMS patients.
  • A strong correlation was found between cfDNA and inflammatory markers.
  • Oxidative stress biomarkers also showed a relationship with altered cfDNA levels.

Abstract

CfDNA parameters are significantly altered in PMS patients and correlate with inflammatory and oxidative stress markers. These findings suggest that cfDNA could serve as a promising biomarker for the early diagnosis and stratification of PMS.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69a91df9d6127c7a504c173fhttps://doi.org/10.1080/01616412.2025.2606230
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