This analysis compares metachronous colorectal cancer risk after segmental and extended resection in patients with Lynch syndrome, suggesting insights for management.
For CRC patients with variants in high-risk LS genes, extended resection can significantly reduce the risk of metachronous CRC but does not lengthen overall survival. Segmental resection with close endoscopic surveillance can be a reasonable alternative, given the opportunity for repeat surgery and/or immune checkpoint blockade.
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Hill et al. (2026) studied this question.
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