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A quasi-experimental study demonstrates higher learning gains in guided inquiry with a GenAI coach, suggesting effectiveness for students with varying knowledge levels.
The challenge of designing generative AI (GenAI) tutors that are both pedagogically sound and effective for guided inquiry remains significant. This paper introduces and evaluates a replicable design framework-termed a Pedagogy-to-Prompt Engineering Framework-that systematically translates established pedagogical models into structured AI interactions. We engineered a 5E-structured GenAI coach by integrating the 5E Learning Cycle as the instructional architecture and the 5S Prompting Principles to govern the AI’s dialogue. The coach was evaluated in a middle school chemistry context (N = 60) focusing on procedural skill acquisition for balancing chemical equations. A quasi-experimental study showed the GenAI group achieved significantly higher learning gains than a control group receiving traditional instruction (t(58) = 2.646, p = 0.011, Cohen’s d = 0.68). Crucially, a Johnson-Neyman analysis revealed that the coach was particularly beneficial for students with lower prior knowledge (pre-test scores < 39.39), effectively narrowing the achievement gap. Furthermore, Lag Sequential Analysis of the interaction logs confirmed that the student-AI dialogue successfully adhered to the intended 5E pedagogical sequence (e.g., Engage → Explore transition, z = 11.157). This study demonstrates that the proposed framework is a viable method for creating effective, scalable AI-driven learning environments. Beyond chemistry, this approach is readily adaptable to other STEM disciplines requiring guided inquiry, such as physics and mathematics. By validating a low-code, pedagogy-first methodology, this work offers a scalable blueprint for instructional designers to bridge the gap between generative AI capabilities and rigorous educational standards.
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Lin et al. (2026) studied this question.
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