Experiments demonstrate enhanced gas exchange and ventilation-perfusion matching in healthy lungs using negative-pressure ventilation, suggesting benefits for clinical applications.
The results indicate that compared with PPV, NPV enhances gas exchange and ventilation-perfusion matching in healthy lungs. Although NPV causes fewer ventilation-perfusion inequalities and reduced dead space ventilation, its efficacy may be limited by increased intrapulmonary shunting during excessive negative end-expiratory pressure levels. These results provide mechanistic support for the physiological benefits of subatmospheric ventilation and may provide a basis for further studies on the refinement of noninvasive and lung-protective ventilation strategies in clinical settings with impaired ventilation-perfusion matching, such as acute respiratory failure, postoperative care, and ventilator weaning.
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Fodor et al. (2026) studied this question.
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