Anticancer Effect of Icaritin on Prostate Cancer via Regulating Abundance of Akkermansiaceae and Vitamin K2 in Intestinal Fecal

Key Points

• The research aims to explore how Icaritin affects prostate cancer by influencing gut microbiota and vitamin K2 levels.
• Analyzed the effect of Icaritin on prostate cancer cells in vitro.
• Measured changes in the abundance of Akkermansiaceae in intestinal fecal samples.
• Assessed levels of vitamin K2 in relation to cancer progression.
• Icaritin treatment significantly reduced prostate cancer cell viability.
• Akkermansiaceae abundance increased following Icaritin treatment.
• Vitamin K2 levels correlated positively with improved cancer outcomes.