Going full circle: Dynamic covalent enzyme immobilisation via visually trackable boronate esters

Glenn Bojanov; Juliette Swit; Francesca Paradisi

doi:10.1039/d5sc08585c

January 1, 2026Chemical ScienceOpen Access

Going full circle: Dynamic covalent enzyme immobilisation via visually trackable boronate esters

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Key Points

This research aims to develop a dynamic covalent strategy for enzyme immobilisation that allows for recycling and waste reduction.
Implemented reversible immobilisation using boronate esters on solid supports.
Evaluated enzyme activity and recycling potential over multiple uses.
Assessed waste generation compared to traditional single-use methods.
Achieved a significant reduction in waste generated from enzyme use.
Showed that enzymes maintained activity over multiple recycling cycles.
Demonstrated visual tracking of immobilised enzymes through the boronate ester technique.

Implication

Research demonstrates reversible enzyme immobilisation to reduce waste in biocatalysis, suggesting a sustainable alternative.

Abstract

Enzyme immobilisation on solid supports enables biocatalyst recycling but generates significant waste due to single-use resins that are discarded when enzyme activity declines. Here we report a reversible immobilisation strategy...

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Cite This Study

Bojanov et al. (2026) studied this question.

synapsesocial.com/papers/69a91e57d6127c7a504c236a https://doi.org/10.1039/d5sc08585c

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Going full circle: Dynamic covalent enzyme immobilisation via visually trackable boronate esters

Key Points

Implication

Abstract

Discussion

Cite This Study

Going full circle: Dynamic covalent enzyme immobilisation via visually trackable boronate esters

Key Points

Implication

Abstract

Discussion

Cite This Study

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