High-throughput single-cell proteomics and transcriptomics from same cells with a nanoliter-scale, spin-transfer approach

Q: What does this research mean for the field?

The high-throughput single-cell multiomic platform enables simultaneous proteomics and transcriptomics analysis from the same cells, providing insights into cellular states and biomolecular networks. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Pranav Dawar; Lye Meng Markillie; Sarah M Williams; Arndt Benecke; Johannes W Bagnoli; Joshua Cantlon-Bruce; Anjali Seth; Carter C Bracken; ljiljana Pasa-Tolic; Ying Zhu; James Michael Fulcher

doi:10.1039/d5lc01008j

January 1, 2026Lab on a ChipOpen Access

High-throughput single-cell proteomics and transcriptomics from same cells with a nanoliter-scale, spin-transfer approach

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Key Points

This research aims to enhance our understanding of cellular diversity and function by integrating proteomics and transcriptomics at the single-cell level.
Utilized a high-throughput single-cell multiomic platform.
Employed a nanoliter-scale approach for sample processing.
Analysed both proteomic and transcriptomic data from individual cells.
Identified distinct cellular states through multiomic profiling.
Provided insights into the regulatory roles of biomolecular networks.
Enhanced sensitivity and specificity in detecting protein and RNA expression levels.

Implication

High-throughput multiomic techniques unveil cellular states in single cells, suggesting advancements in cell biology.

Abstract

Single-cell multiomic platforms provide a comprehensive snapshot of cellular states and cell types by offering critical insights into the spatiotemporal regulation of biomolecular networks at a systems level, thereby defining...

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Cite This Study

Dawar et al. (2026) studied this question.

synapsesocial.com/papers/69a91e65d6127c7a504c25b2 https://doi.org/10.1039/d5lc01008j

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High-throughput single-cell proteomics and transcriptomics from same cells with a nanoliter-scale, spin-transfer approach

Key Points

Implication

Abstract

Discussion

Cite This Study

High-throughput single-cell proteomics and transcriptomics from same cells with a nanoliter-scale, spin-transfer approach

Key Points

Implication

Abstract

Discussion

Cite This Study

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