What is the clinical evidence from this study?

Study design: Observational. Population: Adults undergoing transfemoral transcatheter aortic valve implantation (TAVI) with postoperative echocardiographic assessment (n=786). Intervention: Postoperative TAPSE/PASP ratio assessment vs. Postoperative TAPSE/PASP ratio ≥0.52 mm/mmHg. Primary outcome: Long-term all-cause mortality (HR 0.856 per 0.1 mm/mmHg increase in postoperative TAPSE/PASP, 95% CI 95% CI 0.743-0.988, p=0.033).

What does this research mean for the field?

Lower postoperative TAPSE/PASP (<0.52 mm/mmHg) is independently associated with increased long-term mortality after TAVI. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the association of TAPSE/PASP ratio with long-term mortality following TAVI.

March 5, 2026The Anatolian Journal of Cardiology0 citationsOpen Access

Postoperative Right Ventriculo-Pulmonary Artery Coupling Assessed by TAPSE/PASP as a Predictor of Long-Term Outcomes After TAVI

Q: What are the key findings of this study?

A postoperative TAPSE/PASP ratio <0.52 mm/mmHg independently predicted increased long-term all-cause mortality after TAVI, with HR 0.856 per 0.1 mm/mmHg increase (P=0.033).

Q: What question did this study set out to answer?

To evaluate the association of TAPSE/PASP ratio with long-term mortality following TAVI.

SUSeda Tanyeri UzelKartal Koşuyolu High Specialization Training and Research Hospital BKBerhan KeskinIstanbul Medipol University İBİsmail BALABANKartal Koşuyolu High Specialization Training and Research Hospital

Key Result

A postoperative TAPSE/PASP ratio <0.52 mm/mmHg independently predicted increased long-term all-cause mortality after TAVI, with HR 0.856 per 0.1 mm/mmHg increase (P=0.033).

Key Points

To evaluate the association of TAPSE/PASP ratio with long-term mortality following TAVI.
Assessed postoperative TAPSE/PASP values
Analyzed outcomes related to long-term mortality
Compared findings against established risk parameters
Lower TAPSE/PASP (<0.52 mm/mmHg) linked to higher long-term mortality
Supports TAPSE/PASP as a predictor for postoperative risk
Found independent correlation with mortality rates

Study Design

Type

Observational (n=786)

Multicenter

Structured PICO

Does a postoperative TAPSE/PASP ratio <0.52 mm/mmHg predict long-term all-cause mortality in patients undergoing transfemoral TAVI?

Population

786 consecutive patients who underwent transfemoral transcatheter aortic valve implantation (TAVI), excluding those who experienced in-hospital death or had incomplete echocardiographic/clinical data.

Intervention

Postoperative TAPSE/PASP ratio <0.52 mm/mmHg (measured between postoperative days 3 and 7)

Comparator

Postoperative TAPSE/PASP ratio ≥0.52 mm/mmHg (measured between postoperative days 3 and 7)

Outcome

Long-term all-cause mortalityhard clinical

Main Result

Effect estimate: HR 0.856 per 0.1 mm/mmHg increase in postoperative TAPSE/PASP (95% CI 95% CI 0.743-0.988)

Absolute Event Rate: 12.6% vs 5.1%

p-value: p=0.033

Limitations

Single-center retrospective design limiting generalizability and potential for selection bias
Echocardiographic evaluations limited to a single early postoperative period (days 3-7) without long-term serial imaging
Lack of advanced RV function imaging such as strain analysis and detailed tricuspid regurgitation quantification
Primary endpoint was all-cause mortality without adjudication between cardiovascular and non-cardiovascular deaths
Study period overlapped with the COVID-19 pandemic which may have affected patient selection and follow-up
Potential residual confounding due to unmeasured variables including therapy optimization and heart failure management

Abstract

Lower postoperative TAPSE/PASP (<0.52 mm/mmHg) is independently associated with increased long-term mortality after TAVI, supporting its use for early postoperative risk stratification.

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Cite This Study

Uzel et al. (Thu,) conducted a observational in Adults undergoing transfemoral transcatheter aortic valve implantation (TAVI) with postoperative echocardiographic assessment (n=786). Postoperative TAPSE/PASP ratio assessment vs. Postoperative TAPSE/PASP ratio ≥0.52 mm/mmHg was evaluated on Long-term all-cause mortality (HR 0.856 per 0.1 mm/mmHg increase in postoperative TAPSE/PASP, 95% CI 95% CI 0.743-0.988, p=0.033). A postoperative TAPSE/PASP ratio <0.52 mm/mmHg independently predicted increased long-term all-cause mortality after TAVI, with HR 0.856 per 0.1 mm/mmHg increase (P=0.033).

synapsesocial.com/papers/69a91e65d6127c7a504c25ce https://doi.org/https://doi.org/10.14744/anatoljcardiol.2026.5716