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March 5, 2026ACS Sustainable Chemistry & Engineering

Silk Protein-Based Smart Hydrogels Combining Sutureless Self-Adhesion, Skin Regeneration, and Sensing: A Novel Strategy for Wound Treatment

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Authors

CYChao YangSDShengtao DaiMSMengya Sun

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Overview

Novel hydrogel dressing enhances wound healing and sensing capabilities, indicating promising wound care applications.

Key Points

  • To develop a multifunctional hydrogel dressing that combines self-adhesion, skin regeneration, and sensing for improved wound treatment.
  • Fabrication of a 3S hydrogel dressing using various polymers and dynamic cross-linking techniques.
  • Testing the dressing in full-thickness skin incision and bacteria-infected wound models.
  • Assessing mechanical properties, antibacterial performance, and sensing capabilities.
  • 23.92% increase in collagen deposition compared to controls.
  • 160.19% increase in epidermal thickness after treatment.
  • 14.05% improvement in the wound healing rate with the 3S dressing.
  • Demonstrated real-time detection of human motion and physiological signals.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69a91f0ad6127c7a504c27b2https://doi.org/10.1021/acssuschemeng.5c13003
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