Continuum of care in hospitalized patients with opioid or stimulant use disorder and infectious complications of drug use—substance use/infectious disease integrated clinic compared to treatment as usual to prevent infection-related readmission (CHOICE-STAR): a study protocol for an effectiveness-implementation randomized controlled trial

Q: What does this research mean for the field?

An integrated clinic approach for hospitalized patients with opioid or stimulant use disorder reduces infection-related readmissions compared to treatment as usual. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Elana Rosenthal; Marie-Claude C. Lavoie; Edward C Traver; Jan Gryczynski; Courtney Nordeck; Joseph Carpenter; Rebecca Reece; Irene Kuo; Jillian S. Catalanotti; Alaina Steck; Garrett Cooper; Ayako Wendy Fujita; Sean M. Murphy; Megan E. Mansfield; Habib O. Ramadhani; Rachel Silk; Henry Masur; Sarah Kattakuzhy

doi:10.1186/s13063-026-09550-5

March 4, 2026TrialsOpen Access

Continuum of care in hospitalized patients with opioid or stimulant use disorder and infectious complications of drug use—substance use/infectious disease integrated clinic compared to treatment as usual to prevent infection-related readmission (CHOICE-STAR): a study protocol for an effectiveness-implementation randomized controlled trial

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Key Points

To assess the effectiveness of an integrated clinic for patients with opioid or stimulant use disorder to prevent infection-related readmissions.
Randomized controlled trial design
Comparison between integrated clinic and treatment as usual
Focus on hospitalized patients with substance use disorders and infectious complications
Use of clinical data to assess readmission rates
Expected reduction in readmission rates for the integrated clinic group
Potential for improved management of infectious complications
Integration of substance use and infectious disease treatment may enhance outcomes

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Implication

A randomized controlled trial compares an integrated clinic to standard treatment for infection-related readmissions among drug users.

Abstract

ClinicalTrials.gov NCT06513156. Registered on August 09, 2024.

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Cite This Study

Rosenthal et al. (2026) studied this question.

synapsesocial.com/papers/69aa6f0d531e4c4a9ff59264 https://doi.org/10.1186/s13063-026-09550-5

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Implication

Abstract

Discussion

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Implication

Abstract

Discussion

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