Findings reveal m6A modification regulates inflammatory responses in rheumatoid arthritis, indicating diagnostic potential.
Our findings reveal that METTL3-mediated m6A modification regulates the circINTS4/miR-146b-3p axis, modulating RA-FLS pathogenicity and inflammatory responses. CircINTS4 acts as a molecular sponge for miR-146b-3p and serves as a promising biomarker for RA disease severity. This study provides new insights into the role of m6A methylation and circRNA-miRNA networks in RA, highlighting their potential as diagnostic and therapeutic targets.
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Li et al. (2026) studied this question.
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