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March 6, 2026PLoS Biology0 citationsOpen Access

Developing monoclonal antibody therapies for measles could lead to adverse pathogen evolution

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DKDavid A. KennedyPennsylvania State University

Key Points

  • The aim is to examine the implications of monoclonal antibody therapies for measles and their effect on virus evolution.
  • Analysis of monoclonal antibody therapies in the context of measles
  • Review of recent measles virus resurgence and vaccination effectiveness
  • Consideration of evolutionary biology regarding pathogen adaptation.
  • Monoclonal antibody therapies could facilitate measles virus evolution.
  • Evolution of the virus might reduce vaccine effectiveness.
  • Potential adverse effects may outweigh the benefits of these therapies.

Abstract

Monoclonal antibody therapies are being developed to treat measles in response to its recent resurgence. These therapies risk driving measles virus evolution in ways that might undermine the protection offered by vaccination, outweighing potential benefits.

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Cite This Study

David A. Kennedy (2026) studied this question.

synapsesocial.com/papers/69aa6f0d531e4c4a9ff592efhttps://doi.org/10.1371/journal.pbio.3003701
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Monoclonal antibody therapeutics for infectious diseases: Beyond normal human immunoglobulin2022 · 47 citations
  2. 2Antigenic determinants of measles virus hemagglutinin associated with neurovirulence1994 · 63 citations
  3. 3A Review of the Resurgence of Measles, a Vaccine-Preventable Disease, as Current Concerns Contrast with Past Hopes for Measles Elimination2024 · 81 citations
  4. 4Lessons from the Use of Monoclonal Antibodies to SARS-CoV-2 Spike Protein During the COVID-19 Pandemic2024 · 15 citations
  5. 5SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies2022 · 373 citations