Stimulator of interferon genes (STING) is a transmembrane protein localized to the endoplasmic reticulum that serves as a pivotal sensor of intracellular DNA in innate immunity. Following the detection of pathogen-derived or self-derived DNA in the cytosol, STING activates signaling cascades that promote the production of type I interferons and pro-inflammatory mediators. Beyond its well-established function in host defense, STING has emerged as an important regulatory node in antitumor immune surveillance, maintenance of immune tolerance, neuroinflammatory processes, and metabolic regulation. This patent overview outlines the design, synthesis, and potential therapeutic use of newly developed compounds aimed at treating disorders associated with dysregulated STING signaling.
Shi et al. (Tue,) studied this question.