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This research aims to characterize the effects of Manuka honey and methyl syringate on neutrophil signaling and mediator release.

Manuka honey and its component, methyl syringate, shift neutrophil release profiles from pro-inflammatory while preserving pro-regenerative growth factor release in vitro

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In vitro analysis reveals that Manuka honey and methyl syringate lower inflammation in neutrophils while preserving vital growth factors.

This research aims to characterize the effects of Manuka honey and methyl syringate on neutrophil signaling and mediator release.
Isolated peripheral blood neutrophils from healthy donors using density gradient separation.
Stimulated cells with PMA and treated with varying concentrations of Manuka honey and methyl syringate.
Collected supernatants and analyzed using magnetic bead-based multiplex ELISAs.
Both treatments significantly reduced MPO levels by ≥50% at 3 hours and ≥70% at 6 hours.
IL-8 release was consistently inhibited, with Manuka honey reducing levels to near baseline by 6 hours.
VEGF-A release decreased by ≥70% with Manuka honey, while methyl syringate showed minor reductions at 6 hours.
HGF secretion remained unchanged, indicating preservation of pro-regenerative factors despite reduced inflammation.

Main et al. (2026) studied this question.

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View Full Paper

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Authors

In vitro analysis reveals that Manuka honey and methyl syringate lower inflammation in neutrophils while preserving vital growth factors.

This research aims to characterize the effects of Manuka honey and methyl syringate on neutrophil signaling and mediator release.
Isolated peripheral blood neutrophils from healthy donors using density gradient separation.
Stimulated cells with PMA and treated with varying concentrations of Manuka honey and methyl syringate.
Collected supernatants and analyzed using magnetic bead-based multiplex ELISAs.
Both treatments significantly reduced MPO levels by ≥50% at 3 hours and ≥70% at 6 hours.
IL-8 release was consistently inhibited, with Manuka honey reducing levels to near baseline by 6 hours.
VEGF-A release decreased by ≥70% with Manuka honey, while methyl syringate showed minor reductions at 6 hours.
HGF secretion remained unchanged, indicating preservation of pro-regenerative factors despite reduced inflammation.

Main et al. (2026) studied this question.

View Full Paper

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Bookmark