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March 6, 2026European journal of medical research0 citationsOpen Access

Multi-omics association investigation of the relationship between gut microbiota and the development of colorectal cancer

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SYShunying YuShanghai Jiao Tong UniversityFZFang ZhongJiangnan UniversityYWYuqi WeiShanxi University

Key Points

  • The study aims to investigate the link between gut microbiota and the progression of colorectal cancer.
  • Analyzed intestinal mucosal bacteria in relation to bile acids and short-chain fatty acids.
  • Examined the transition from benign hyperplasia to neoplastic lesions in the colon.
  • Utilized multi-omics approaches for a comprehensive analysis.
  • Identified a potential association between specific gut bacteria and bile acids.
  • Showed a link between gut microbiota and the development of neoplastic lesions in colorectal cancer.

Abstract

Our study initially suggests a potential association between intestinal mucosal bacteria and bile acids as well as short-chain fatty acids in the progression from benign hyperplasia to neoplastic lesions in the colon, providing new clues for understanding the role of gut microbiota in the process of colorectal cancer development.

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Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/69aa6f3c531e4c4a9ff594a3https://doi.org/10.1186/s40001-026-04102-8
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