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March 6, 2026Interventional Radiology0 citationsOpen Access

Hepatic Artery Embolization Reduces Tumor-infiltrating-CD8-positive Lymphocytes in an Orthotopic Rat Hepatocellular Carcinoma Model

HTHaruyuki TakakiHyogo UniversityRWReona WadaHyogo Medical UniversityEUEisuke UeshimaKobe University

Key Points

  • This research aims to assess how hepatic artery embolization influences CD8-positive lymphocytes within tumor environments.
  • Evaluated the effects of hepatic artery embolization in a rat model of hepatocellular carcinoma.
  • Assessed changes in tumor-infiltrating CD8-positive lymphocytes using flow cytometry and immunohistochemistry.
  • Utilized an orthotopic rat model to closely mimic human tumor conditions.
  • Hepatic artery embolization significantly reduced the number of tumor-infiltrating CD8-positive lymphocytes.
  • The changes indicate a potential modulation of the tumor immune microenvironment following treatment.

Abstract

Purpose: Hepatic artery embolization is a locoregional treatment for hepatocellular carcinoma that may modulate the tumor immune microenvironment. However, its effects on tumor-infiltrating cluster of differentiation 8-positive lymphocytes remain unclear. This study evaluates changes in tumor-infiltrating cluster of differentiation 8-positive lymphocytes following hepatic artery embolization in an orthotopic rat hepatocellular carcinoma model using flow cytometry and immunohistochemistry.

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Cite This Study

Takaki et al. (2026) studied this question.

synapsesocial.com/papers/69aa6f3c531e4c4a9ff59564https://doi.org/10.22575/interventionalradiology.2025-0047
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