Analysis finds antibody index values may decrease confirmatory testing for syphilis, suggesting improved efficiency in diagnostics.
We assessed utility of antibody index values from treponemal immunoassays against confirmatory tests following reverse syphilis algorithm. We tested sera collected from a population at increased risk and established thresholds for treponemal immunoassays. High concordance with confirmatory tests was observed, indicating potential use of assay specific threshold to reduce testing.
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Shukla et al. (2026) studied this question.
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